GRIP1 (gene)

Glutamate receptor interacting protein 1

PDB rendering based on 1m5z.

Available structures
PDB	1m5z, 1n7e, 1n7f, 1p1d, 1p1e, 1v5q

Identifiers

Symbols

GRIP1; GRIP

External IDs

OMIM: 604597 MGI: 1921303 HomoloGene: 12938 GeneCards: GRIP1 Gene

Gene Ontology
Molecular function	• transcription coactivator activity • beta-catenin binding • protein C-terminus binding • receptor signaling complex scaffold activity • androgen receptor binding
Cellular component	• intracellular • endoplasmic reticulum • cytosol • plasma membrane • cytoplasmic membrane-bounded vesicle • cell junction • synapse • postsynaptic membrane
Biological process	• synaptic transmission • androgen receptor signaling pathway • intracellular signal transduction • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
66.74 – 67.2 Mb

Chr 10:
118.89 – 119.52 Mb

PubMed search

[1]

[2]

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.^[1]^[2]

Interactions

GRIP1 (gene) has been shown to interact with GRIA4,^[3] Metabotropic glutamate receptor 3,^[3] GRIK2,^[4]^[3] GRIK3,^[3] GRIPAP1,^[5] GRIA2^[3] and GRIA3.^[3]

References

^ Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R (Apr 1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron 22 (3): 511–24. doi:10.1016/S0896-6273(00)80706-0. PMID 10197531.
^ "Entrez Gene: GRIP1 glutamate receptor interacting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23426.
^ ^a ^b ^c ^d ^e ^f Hirbec, Hélène; Perestenko Olga, Nishimune Atsushi, Meyer Guido, Nakanishi Shigetada, Henley Jeremy M, Dev Kumlesh K (May. 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. (United States) 277 (18): 15221–4. doi:10.1074/jbc.C200112200. ISSN 0021-9258. PMID 11891216.
^ Hirbec, Hélène; Francis Joanna C, Lauri Sari E, Braithwaite Steven P, Coussen Françoise, Mulle Christophe, Dev Kumlesh K, Coutinho Victoria, Meyer Guido, Isaac John T R, Collingridge Graham L, Henley Jeremy M, Couthino Victoria (Feb. 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron (United States) 37 (4): 625–38. doi:10.1016/S0896-6273(02)01191-1. ISSN 0896-6273. PMID 12597860.
^ Ye, B; Liao D, Zhang X, Zhang P, Dong H, Huganir R L (Jun. 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron (UNITED STATES) 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. ISSN 0896-6273. PMID 10896157.

Irvine RA, Ma H, Yu MC, et al. (2000). "Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length.". Hum. Mol. Genet. 9 (2): 267–74. doi:10.1093/hmg/9.2.267. PMID 10607837.
Teyssier C, Belguise K, Galtier F, Chalbos D (2001). "Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.". J. Biol. Chem. 276 (39): 36361–9. doi:10.1074/jbc.M101806200. PMID 11477071.
Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.". Mol. Pharmacol. 60 (5): 916–23. PMID 11641419.
Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
Braithwaite SP, Xia H, Malenka RC (2002). "Differential roles for NSF and GRIP/ABP in AMPA receptor cycling". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7096–101. doi:10.1073/pnas.102156099. PMC 124534. PMID 12011465. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124534.
Kotaja N, Karvonen U, Jänne OA, Palvimo JJ (2002). "The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1". J. Biol. Chem. 277 (33): 30283–8. doi:10.1074/jbc.M204768200. PMID 12060666.
Min G, Kim H, Bae Y, et al. (2002). "Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators". J. Biol. Chem. 277 (37): 34626–33. doi:10.1074/jbc.M205239200. PMID 12114525.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell. Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Charych EI, Yu W, Li R, et al. (2004). "A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain". J. Biol. Chem. 279 (37): 38978–90. doi:10.1074/jbc.M405786200. PMID 15226318.
Sugatani J, Nishitani S, Yamakawa K, et al. (2005). "Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1". Mol. Pharmacol. 67 (3): 845–55. doi:10.1124/mol.104.007161. PMID 15557560.
Lin DY, Fang HI, Ma AH, et al. (2004). "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMC 533990. PMID 15572661. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=533990.
Yang CK, Kim JH, Li H, Stallcup MR (2006). "Differential use of functional domains by CoCoA in its synergistic coactivator function with β-catenin or GRIP1". J. Biol. Chem. 281 (6): 3389–97. doi:10.1074/jbc.M510403200. PMC 1626527. PMID 16344550. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1626527.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
Liu PY, Hsieh TY, Chou WY, Huang SM (2006). "Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains". FEBS J. 273 (10): 2172–83. doi:10.1111/j.1742-4658.2006.05231.x. PMID 16649994.
Tsai SJ, Liou YJ, Liao DL, et al. (2007). "No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (3): 752–5. doi:10.1016/j.pnpbp.2007.01.015. PMID 17303296.

PDB gallery

1m5z: The PDZ7 of Glutamate Receptor Interacting Protein Binds to its Target via a Novel Hydrophobic Surface Area

1n7e: Crystal structure of the sixth PDZ domain of GRIP1

1n7f: Crystal structure of the sixth PDZ domain of GRIP1 in complex with liprin C-terminal peptide

1p1d: Structural Insights into the Inter-domain Chaperoning of Tandem PDZ Domains in Glutamate Receptor Interacting Proteins

1v5q: Solution Structure of the PDZ Domain from Mouse Glutamate Receptor Interacting Protein 1A-L (GRIP1) Homolog

GRIP1 (gene)

Interactions

References

Further reading